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Thoracic Surgical Oncology Group

In conjunction with the Fiona and Stanley Druckenmiller Center for Lung Cancer Research at Memorial Sloan Kettering Cancer Center and the AATS, the Thoracic Surgery Oncology Group (TSOG) was formed in 2017 to support a network of North American thoracic surgery clinical trials relevant to physicians and their patients—something that had been missing from the landscape in recent years. The overarching goal of the group is to improve the understanding of thoracic oncologic diseases and enhance patient care through the administration of multi-site trials focused on recent advances in precision medicine, immunotherapy, and intraoperative imaging.

TSOG will actively accrue patients to relevant investigator-initiated clinical trials, as well as select industry-sponsored clinical trials, designed to improve outcomes for patients with thoracic malignancies. Learn more about joining the network and current RFA.

Executive Board

Chair

David R. Jones, MD

Memorial Sloan Kettering Cancer Center

Member

Raphael Bueno, MD

Brigham and Women's Hospital

Member

David H. Harpole, MD

Duke University

Member

Ara A. Vaporciyan, MD

The University of Texas MD Anderson Cancer Center

Current Sites and Principal Investigators

Allegheny General Hospital Cancer CenterBenny Weksler, MD
Baylor College of MedicineBryan Burt, MD
Brigham and Women’s HospitalRaphael Bueno, MD
Case Western Reserve University School of MedicinePhilip A. Linden, MD
Centre Hospitalier de l’Université de Montréal (CHUM)Moishe Liberman, MD
Duke UniversityDavid Harpole, MD
Fox Chase Cancer CenterStacy Su, MD
Massachusetts General HospitalMichael Lanuti, MD
Mayo Clinic JacksonvilleIan Makey, MD
Mayo Clinic RochesterDennis Wigle, MD
McMaster University (St. Joseph’s Hamilton)Yaron Shargall, MD
Memorial Sloan Kettering Cancer CenterDavid R. Jones, MD
NYU Langone Medical CenterHarvey I. Pass, MD
Roswell Park Comprehensive Cancer CenterSai Yendamuri, MD
Rush University Medical CenterChristopher W. Seder, MD
Stanford UniversityDouglas Liou, MD
The University of Texas MD Anderson Cancer CenterAra Vaporciyan, MD
Thomas Jefferson UniversityNathaniel R. Evans III, MD
University of California Los AngelesJay M. Lee, MD
University Hospitals Cleveland Medical CenterPhilip Linden, MD
University of MichiganJules Lin, MD
University of PennsylvaniaDoraid Jarrar, MD
University of PittsburghJames Luketich, MD
University of Southern CaliforniaScott Atay, MD
University of Toronto (UHN)Thomas Waddell, MD
Vanderbilt UniversityErin Gillaspie, MD
Washington University in St. LouisBenjamin Kozower, MD
West Virginia UniversityGhulam Abbas, MD


TSOG 101

Dr. James M. Isbell, MD, MSCI, Memorial Sloan Kettering Cancer Center

“Study to evaluate perioperative circulating tumor DNA as prognostic biomarker in patients undergoing neoadjuvant therapy for resectable non-small cell lung cancer.” —TSOG 101

The aim of this study is to determine the validity of using quantitative ctDNA as a surrogate marker for pathologic treatment response in patients receiving neoadjuvant therapy for stage IIA-IIIB NSCLC who are undergoing curative-intent resection.

The second aim is to determine, in patients with NSCLC, the prognostic value of persistent ctDNA following curative-intent resection for predicting recurrence, disease-free survival, and overall survival.

The third aim is to correlate the percent change in levels of ctDNA to percent change in the SUVmax of the primary tumor on 18-FDG-PET scan before and after neoadjuvant therapy.

TSOG 102

Dr. James Huang, MD Memorial Sloan Kettering Cancer Center

“Registry trial of active surveillance for multifocal ground glass opacities (GGOs).” —TSOG 102

The primary objective of this study is to determine lung cancer–specific survival at 5 years among patients undergoing active surveillance for GGOs.

The secondary objective is to determine the following endpoints among patients undergoing active surveillance for GGOs: overall survival, freedom from progression (any), freedom from nodal progression, freedom from distant progression, cumulative incidence of intervention (biopsy or resection), cumulative incidence of a new GGO, and cumulative incidence of confirmed lung cancer diagnosis.

TSOG 103

Dr. Mara Antonoff, MD The University of Texas MD Anderson Cancer Center

“The role of multimodality management in risk-stratified patients with lung-limited metastatic colorectal cancer.” —TSOG 103

The primary objectives of this study are to compare recurrence-free survival in patients with “low-risk” lung-limited mCRC undergoing pulmonary metastasectomy with or without perioperative chemotherapy, as well as to compare overall survival in patients with “high-risk” lung-limited mCRC receiving systemic chemotherapy with or without surgical resection.

Additional exploratory objectives involve the evaluation of changes in ctDNA following surgical resection and/or systemic chemotherapy in patients with lung-limited mCRC.

TSOG 104

Dr. Harvey Pass, MD New York University Langone Medical Center

"A prospective, non interventional, trial evaluating the diagnostic accuracy of FBLN3
for mesothelioma pleural effusions." —TSOG 104

The primary objective of this study is to prospectively create a virtual reference set of pleural effusion samples from patients referred for treatment of a pleural effusion which can be used for future biomarker discovery and validation studies.

The secondary objectives using pleural effusion samples, will be to calculate the FBLN3 concentration and compare the levels between the cohorts collected
including non-mesothelioma benign, non-mesothelioma malignant, and mesothelioma.

We will determine the AUC using FBLN3 to distinguish pleural effusions of mesothelioma vs non mesothelioma individuals.

For additional details about TSOG and how to get involved, please contact:

Maria Singh
Project Manager, Memorial Sloan Kettering Cancer Center
singhm1@mskcc.org

Alain Vincent
Clinical Research Manager, Memorial Sloan Kettering Cancer Center
vincenta@mskcc.org

Erin Carroll
Research Project Associate, Memorial Sloan Kettering Cancer Center
carrolle@mskcc.org