133. Living-Donor Segmental Lung Transplantation for Pediatric Patients

Objective: Living-donor lobar lung transplantation is a viable option for patients too ill to survive a long waiting time for cadaveric donors. Usually, the right and left lower lobes from 2 healthy donors are implanted in the recipient in place of whole right and left lungs. However, an adult lower lobe may be too big for a small pediatric patient. The aim of this study was to evaluate the outcome of living-donor segmental lung transplantation (LDSLT) for pediatric patients.
Methods: Between August 2009 and May 2021, we performed LDSLT in 6 critically ill pediatric patients including one patient on a ventilator and another patient on ECMO. There were 4 male and 2 female patients, with ages ranging from 4 to 15 years (average, 8.3 years). The recipient height ranged from 94.4 to 123 cm (average, 109.4 cm), and the weight ranged from 12.3 to 16.8 kg (average, 15.3 kg). The diagnoses included complications of allogeneic hematopoietic stem cell transplantation (n = 4) and pulmonary fibrosis (n = 2). Donors were 10 parents and one grandmother. All patients received bilateral lung transplantation under cardiopulmonary bypass. A basal segment and a lower lobe were implanted in three patients. A basal segment and a S6 segment were implanted in other three patients. In two patients, the right S6 segmental graft was rotated and implanted as the left lung (Figure). All data were analyzed retrospectively as of September 2021.
Results: Among the 9 segmental grafts implanted, 7 segmental grafts functioned well after reperfusion. Two rotated S6 segmental grafts became congestive; one required graft extraction and the other required venous repair which was successful. There was one hospital death (14 days) due to sepsis and one late death (9 years) due to leukoencephalopathy. The rest of four patients are currently alive. The 1 and 3-year survival was 83.3% (Figure). There was no complication related to segmentectomy in the donors.
Conclusion: LDSLT was a technically difficult but feasible procedure with acceptable outcome for small pediatric patients whose chest cavities were too small for adult lower lobe implantation.

Hiroshi Date (1), Daisuke Nakajima (2), Satona Tanaka (2), Tadashi Ikeda (3), Shiro Baba (4), Takenori Suga (4), Akihiro Ohsumi (2), (1) Department of Thoracic Surgery , Kyoto University Graduate School of Medicine, Kyoto, Kyoto, (2) Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, (3) Department of Cardiovascular Surgery, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, (4) Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Kyoto

Dirk Van Raemdonck

Invited Discussant

Dirk Van Raemdonck is a Professor of Surgery at the Catholic University Leuven and a member of staff in the department of thoracic surgery at the University Hospitals Leuven, Belgium. He is the surgical director of the Leuven Lung Transplant Group with an annual volume of about 70 lung transplants over the last 5 years and a total of nearly 1300 lung transplants since 1991. He holds the position of Director of the Leuven Transplant Center and serves on the Board of Supervision of Eurotransplant International Foundation. He is ESTS past-president and current president of the UEMS Section of Thoracic Surgery. He is the President of the Royal Academy for Medicine in Belgium. He holds the position of editor-in-chief of the Journal of Heart and Lung Transplantation Open.

Hiroshi Date

Abstract Presenter

Hiroshi Date, MD, serves as the Chairman and Professor in the Department of Thoracic Surgery at Kyoto University, Japan. After graduating from Okayama University School of Medicine in 1984, he underwent training under Drs. Joel D. Cooper and G. Alexander Patterson at Washington University, both as a research fellow from 1989 to 1991 and a clinical lung transplant fellow from 1994 to 1995. He also spent a year, from 1993 to 1994, as a general thoracic fellow at The Cleveland Clinic Foundation.

In 1998, Dr. Date achieved a significant milestone by successfully performing the first living-donor lobar lung transplantation in Japan. Since then, he has conducted approximately 400 lung transplants, resulting in a 70% survival rate at the 10-year mark. Dr. Date has performed more than 4,000 thoracotomies and has authored more than 600 peer-reviewed publications in various fields of general thoracic surgery including thoracic malignancy and lung transplantation.

Specialties: Transplant, Treatment/Procedure/Operation/Surgery, Transplantation--Lung, Lung Transplantion, General Thoracic, Thoracic, Transplant, Treatment/Procedure/Operation/Surgery, Lung--Transplantation