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following concurrent chemotherapy and high-dose radiation
for stage IIIA non–small cell lung cancer
Jessica S. Donington, MD, Rebecca
Paulus, BS, Martin J. Edelman, MD, Mark J. Krasna, MD,
Quynh-Thu Le, MD, PhD, Mohan Suntharalingam, MD, Billy
W. Loo Jr., MD, PhD, Chen Hu, PhD, Jeffrey D. Bradley,
MD, for the NRG Oncology Lung Group
was performed safely following full-dose concurrent
chemoradiotherapy in these multi-institutional
High-dose induction chemoradiation for lung cancer: The
past is prologue
Altorki, MD, Brendon Stiles, MD
Important data from 2 phase 2 trials
with chemotherapy plus high-dose radiation before
stage IIIA NSCLC surgery show that lobar resection
can be done safely but complex resections carry 20%
Burn, baby, burn
Sesti, MD, Subroto Paul, MD, MPH
Full-dose preoperative radiation (60
Gy) can be given to patients with stage IIIA
non–small cell lung cancer with acceptable
mortality at selected centers.
resection compared with stereotactic body radiation
therapy and ablation for early stage non–small cell lung
cancer: A National Cancer Database study
Jing Wu, MD, Harrison X. Bai, MD,
Lilian Chan, MS, Chang Su, MS, Paul J. Zhang, MD, Li
Yang, MD, Zishu Zhang, MD
results suggest SLR may be associated with increased OS
in patients with early-stage NSCLC compared with SBRT
The wizard of OS: Is overall survival better after
sublobar resection versus stereotactic radiation or
Lin, MD, FACS, FCCP
The authors report better survival
with sublobar resection versus stereotactic
radiation or ablation, although data in the
National Cancer Database are limited and future
prospective studies are needed.
To wedge or not to wedge
E. Denlinger, MD
A retrospective review of a large
administrative database suggests that the most
effective alternative to lobectomy for early-stage
lung cancer is a sublobar resection followed by
SBRT and thermal ablation.
Can big data effectively answer important clinical
Comparisons of sublobar resection,
SBRT, or percutaneous thermal ablation for
treatment of early stage NSCLC are difficult in a
Segmental resection for the
non–small cell lung cancer in the posterior segment of
left upper lobe.
of robotic versus thoracoscopic segmentectomy for
early-stage lung cancer: A multi-institutional propensity
Yajie Zhang, MD, PhD, Chun Chen,
MD, PhD, Jian Hu, MD, PhD, Yu Han, MD, Maosheng Huang,
MD, Jie Xiang, MD, Hecheng Li, MD, PhD
segmentectomy resulted in comparable short-term
outcomes compared with VATS segmentectomy for early
NSCLC. A potential benefit of robotics might relate to
an improved N1 lymph node retrieval.
Robot-assisted segmentectomy is safe and expensive—What
is the debate?
J. Song, MD, Raja M. Flores, MD
Robot-assisted segmentectomy is safe
but expensive and has not been shown to provide
clinical benefits relative to video-assisted
Video-assisted thoracoscopic surgery versus robotic
assisted surgery: Are we asking the right question?
S. Kim, MD, FACS, Ankit Bharat, MD, FACS
Both video-assisted thoracoscopic
and robotic segmentectomy are effective and safe in
the hands of expert surgeons in treating early lung
LUNG CANCER: INVITED EXPERT OPINION
considerations for neoadjuvant immunotherapy in non–small
cell lung cancer
Brendon M. Stiles, MD, Boris
Sepesi, MD, Stephen R. Broderick, MD, Matthew J. Bott,
interest exists in preoperative immunotherapy for
patients with surgically resectable lung cancer.
Surgeons should be actively involved in trial design,
patient selection, and outcome evaluation.
Why does neoadjuvant therapy suddenly make sense for
early stage non–small cell lung cancer?
Donington, MD, MSCR
Trials of neoadjuvant immune
checkpoint inhibitors have generated great
enthusiasm, but we must be cognizant of the
potential for negative influence on short-term
surgical outcomes in early-stage patients.
survival after lung transplantation for adults requiring
preoperative invasive mechanical ventilation: A national
Barbara C.S. Hamilton, MD, MAS,
Gabriela R. Dincheva, BS, Michael A. Matthay, MD,
Steven Hays, MD, Jonathan P. Singer, MD, MS, Marek
Brzezinski, MD, Jasleen Kukreja, MD, MPH
decade has shown significant improvements in survival
for lung transplantation in mechanically ventilated
Survival of the fittest: Survival improved in patients
on mechanical ventilation pretransplant, but frailty
While survival has improved in
patients on mechanical ventilation pre-lung
transplant, assessing frailty is critical, as these
patients continue to have worse survival than
Rage against the machine (ventilator that is)
B. Erasmus, MB, ChB, MD, Si M. Pham, MD, Kevin P.
Despite improvements in recipient
survival following lung transplant with
pretransplant mechanical ventilation, the quest for
better bridging strategies continues.