following is a collection of featured thoracic articles
from the Journal of Thoracic and Cardiovascular
Surgery (JTCVS). To read the latest issue, or
browse the feature video library and other journal
highlights, please visit www.jtcvs.org.
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low-dose computed tomography as a regular health
examination among Chinese hospital employees
MD, Sanghoon Jheon, MD, Huimin Li, MD, Huibiao Zhang,
MD, Yaozeng Xie, MD, Bin Qian, MD, Kaihong Lin, MD,
Shengping Wang, MD, Chen Fu, MS, Hong Hu, MD, Ying
Zheng, MSc, Yuan Li, MD, Haiquan Chen, MD
LDCT detected lung cancer in a
significant proportion of young, female, and nonsmoking
employees. The vast majority of these lung cancers were
early stage with an extremely good prognosis.
On-demand computed tomography screening for lung
cancer—some surprising results
Richard I. Whyte, MD, MBA
lung cancer screening study of Chinese health care
workers challenges the notion that CT screening
should be reserved for individuals traditionally
felt to be of “high risk.”
Pay attention to low-risk populations for lung cancer,
but cautiously interpret ground-glass nodules screened
by low-dose computed tomography scan
Ke-Neng Chen, MD, PhD
traditional high-risk population for lung cancer
has been changing. Nonetheless, it remains
important to avoid overdiagnosis and overtreatment
of ground-glass nodules.
The role of low-dose computed tomography for lung
cancer screening among the nonsmoking Asian population
I-Hsien Lee, MD, Chung-Yu Chen, MD,
necessity and efficacy of low-dose computed
tomography screening for lung cancer, and also the
risk prediction model, should be verified in Asian
The changing risk paradigm in lung cancer: Are we
opening Pandora's box?
Simran K. Randhawa, MD, Varun Puri,
cancer screening guidelines may need to be
individualized to populations.
lobectomy for centrally located non–small cell lung
cancer: A propensity score–weighted comparison with
thoracoscopic and open surgery
Tong Qiu, MD,
Yandong Zhao, MD, PhD, Yunpeng Xuan, MD, Yi Qin, MD,
Zejun Niu, MD, Yi Shen, MD, Wenjie Jiao, MD, PhD
Compared with VATS and open techniques,
robotic sleeve lobectomy is a safe, feasible, and
effective procedure with a similar oncologic outcome.
Why so many sleeve resections and pneumonectomies and
why the nonabsorbable suture?
Robert J. Cerfolio, MD, MBA, FACS,
for lung cancer should be rarely performed.
Maximum surgery through minimal incisions
Richard Lazzaro, MD, Byron Patton, MD
sleeve lobectomy is a safe and feasible procedure.
Training programs and mentorship opportunities will
further the safe adoption of maximal surgery through
Sleeve lobectomy for centrally located non–small cell
lung cancer: Should the approach be a matter of debate?
Arthur Vieira, MD, Paula A. Ugalde, MD
surgery led to the best postoperative outcomes
after sleeve lobectomy when compared with VATS and
thoracotomy. Robotic platform is a valuable
surgical tool for centrally located lung cancers.
Minimally invasive sleeve lobectomy—from case report
curiosity to standard of care?
Nirmal K. Veeramachaneni, MD
and VATS sleeve lobectomy is feasible. Surgeons who
have reported excellent results have considerable
experience with minimally invasive techniques.
CANCER: BASIC SCIENCE
expansile nanoparticles improve survival following
cytoreductive surgery in pleural mesothelioma xenografts
Chu, MD, Rong Liu, MD, PhD, Aaron Colby, PhD, Claire de
Forcrand, MPH, Robert F. Padera, MD, PhD, Mark W.
Grinstaff, PhD, Yolonda L. Colson, MD, PhD
Delivery of paclitaxel via nanoparticles
confers prolonged survival in pleural mesothelioma as
single modality therapy for limited disease and in
combination with cytoreduction for advanced disease.
Local chemotherapy with nanoparticles: A ray of light
in the dark?
Shota Nakamura, MD, Toyofumi F.
novel therapeutic method using intrathoracic
injection of paclitaxel-loaded expansile
nanoparticles is promising based on its
experimental model mimicking the clinical scenario
One nano-step for murinekind, one giant leap for
Jordan S. Dutcher, BS, Jonathan
D’Cunha, MD, PhD
review a well-executed study evaluating the
increased efficacy and improved survival of
nanoparticle-targeted drug delivery in a murine
Go small or go home
Anthony W. Kim, MD, Usman Ahmad, MD
benefits of nanoparticle therapy observed in the
murine model of malignant pleural mesothelioma are
both pioneering and foundational.
INVITED EXPERT OPINION
Life in a world
with per oral endoscopic myotomy: The ever-changing
landscape in management of achalasia
MD, PhD, Sudish C. Murthy, MD, PhD
POEM seems to be a more effective tool
in treating achalasia than pneumatic dilation. But is it
as good as a minimally invasive Heller myotomy?
to preserve allograft function after lung transplant:
Systematic review and meta-analysis
Davidson, MBBS, MRCS, Danielle Franklin, MBBS, Sacheen
Kumar, PhD, FRCS, Borzoueh Mohammadi, MBBS, FRCS,
Khaled Dawas, MD, FRCS, Simon Eaton, PhD, Joe Curry,
MBBS, FRCS, Paolo De Coppi, PhD, FRCS, Nima
Abbassi-Ghadi, PhD, FRCS
In this meta-analysis of patients with
lung transplant undergoing antireflux surgery (ARS),
the decline observed in rate of change of the FEV1 can
be shown to plateau, which may be indicative of a
reduction of the influence of BOS.
The heartburn of lung transplantation
Ross M. Bremner, MD, PhD
fundoplication in patients with gastroesophageal
reflux disease may help to protect the transplanted
lungs from rejection.
Gastroesophageal reflux and lung allograft dysfunction:
Need to improve detection and clinical reporting
Usman Ahmad, MD, Charles R. Lane, MD
can be multifactorial and needs to be studied in
the context of esophageal and gastric motility
disorders that are common after lung
transplantation. In addition, identification of
biochemical markers of gastric content aspiration
in BAL fluid will help in the study of reflux and
measuring efficacy of its treatment.
The burning questions of reflux management in lung
Hai Salfity, MD, MPH, Matthew Hartwig,
management of gastroesophageal reflux disease may
prolong allograft function in lung transplant
to preserve allograft function after lung transplant.