The following is a collection of
featured thoracic articles from the Journal of Thoracic and Cardiovascular
Surgery (JTCVS). To read the latest issue, or
browse the feature video library and other journal
highlights, please visit www.jtcvs.org.
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low-dose computed tomography as a regular health
examination among Chinese hospital employees
Yang Zhang, MD, Sanghoon Jheon,
MD, Huimin Li, MD, Huibiao Zhang, MD, Yaozeng Xie, MD,
Bin Qian, MD, Kaihong Lin, MD, Shengping Wang, MD, Chen
Fu, MS, Hong Hu, MD, Ying Zheng, MSc, Yuan Li, MD,
Haiquan Chen, MD
detected lung cancer in a significant proportion of
young, female, and nonsmoking employees. The vast
majority of these lung cancers were early stage with an
extremely good prognosis.
On-demand computed tomography screening for lung
cancer—some surprising results
I. Whyte, MD, MBA
This lung cancer screening study of
Chinese health care workers challenges the notion
that CT screening should be reserved for
individuals traditionally felt to be of “high
Pay attention to low-risk populations for lung cancer,
but cautiously interpret ground-glass nodules screened
by low-dose computed tomography scan
Chen, MD, PhD
The traditional high-risk population
for lung cancer has been changing. Nonetheless, it
remains important to avoid overdiagnosis and
overtreatment of ground-glass nodules.
The role of low-dose computed tomography for lung
cancer screening among the nonsmoking Asian population
Lee, MD, Chung-Yu Chen, MD, PhD
The necessity and efficacy of
low-dose computed tomography screening for lung
cancer, and also the risk prediction model, should
be verified in Asian never-smokers.
The changing risk paradigm in lung cancer: Are we
opening Pandora's box?
K. Randhawa, MD, Varun Puri, MD, MSCI
Lung cancer screening guidelines may
need to be individualized to populations.
lobectomy for centrally located non–small cell lung
cancer: A propensity score–weighted comparison with
thoracoscopic and open surgery
Tong Qiu, MD, Yandong Zhao, MD,
PhD, Yunpeng Xuan, MD, Yi Qin, MD, Zejun Niu, MD, Yi
Shen, MD, Wenjie Jiao, MD, PhD
with VATS and open techniques, robotic sleeve lobectomy
is a safe, feasible, and effective procedure with a
similar oncologic outcome.
Why so many sleeve resections and pneumonectomies and
why the nonabsorbable suture?
J. Cerfolio, MD, MBA, FACS, FCCP
Pneumonectomy for lung cancer should
be rarely performed.
Maximum surgery through minimal incisions
Lazzaro, MD, Byron Patton, MD
Robotic sleeve lobectomy is a safe
and feasible procedure. Training programs and
mentorship opportunities will further the safe
adoption of maximal surgery through minimal
Sleeve lobectomy for centrally located non–small cell
lung cancer: Should the approach be a matter of debate?
MD, Paula A. Ugalde, MD
Robotic surgery led to the best
postoperative outcomes after sleeve lobectomy when
compared with VATS and thoracotomy. Robotic
platform is a valuable surgical tool for centrally
located lung cancers.
Minimally invasive sleeve lobectomy—from case report
curiosity to standard of care?
K. Veeramachaneni, MD
Robotic and VATS sleeve lobectomy is
feasible. Surgeons who have reported excellent
results have considerable experience with minimally
LUNG CANCER: BASIC SCIENCE
expansile nanoparticles improve survival following
cytoreductive surgery in pleural mesothelioma xenografts
Ngoc-Quynh Chu, MD, Rong Liu, MD,
PhD, Aaron Colby, PhD, Claire de Forcrand, MPH, Robert
F. Padera, MD, PhD, Mark W. Grinstaff, PhD, Yolonda L.
Colson, MD, PhD
of paclitaxel via nanoparticles confers prolonged
survival in pleural mesothelioma as single modality
therapy for limited disease and in combination with
cytoreduction for advanced disease.
Local chemotherapy with nanoparticles: A ray of light
in the dark?
Nakamura, MD, Toyofumi F. Chen-Yoshikawa, MD
A novel therapeutic method using
intrathoracic injection of paclitaxel-loaded
expansile nanoparticles is promising based on its
experimental model mimicking the clinical scenario
One nano-step for murinekind, one giant leap for
S. Dutcher, BS, Jonathan D’Cunha, MD, PhD
We review a well-executed study
evaluating the increased efficacy and improved
survival of nanoparticle-targeted drug delivery in
a murine mesothelioma model.
Go small or go home
W. Kim, MD, Usman Ahmad, MD
The benefits of nanoparticle therapy
observed in the murine model of malignant pleural
mesothelioma are both pioneering and foundational.
ESOPHAGUS: INVITED EXPERT OPINION
Life in a world
with per oral endoscopic myotomy: The ever-changing
landscape in management of achalasia
Siva Raja, MD, PhD, Sudish C.
Murthy, MD, PhD
seems to be a more effective tool in treating achalasia
than pneumatic dilation. But is it as good as a
minimally invasive Heller myotomy?
to preserve allograft function after lung transplant:
Systematic review and meta-analysis
Joseph R. Davidson, MBBS, MRCS,
Danielle Franklin, MBBS, Sacheen Kumar, PhD, FRCS,
Borzoueh Mohammadi, MBBS, FRCS, Khaled Dawas, MD, FRCS,
Simon Eaton, PhD, Joe Curry, MBBS, FRCS, Paolo De
Coppi, PhD, FRCS, Nima Abbassi-Ghadi, PhD, FRCS
meta-analysis of patients with lung transplant
undergoing antireflux surgery (ARS), the decline
observed in rate of change of the FEV1 can be shown to
plateau, which may be indicative of a reduction of the
influence of BOS.
The heartburn of lung transplantation
Bremner, MD, PhD
Posttransplant fundoplication in
patients with gastroesophageal reflux disease may
help to protect the transplanted lungs from
Gastroesophageal reflux and lung allograft dysfunction:
Need to improve detection and clinical reporting
Ahmad, MD, Charles R. Lane, MD
GERD can be multifactorial and needs
to be studied in the context of esophageal and
gastric motility disorders that are common after
lung transplantation. In addition, identification
of biochemical markers of gastric content
aspiration in BAL fluid will help in the study of
reflux and measuring efficacy of its treatment.
The burning questions of reflux management in lung
Salfity, MD, MPH, Matthew Hartwig, MD
Surgical management of gastroesophageal
reflux disease may prolong allograft function in
lung transplant patients.
Fundoplication to preserve
allograft function after lung transplant.