The following is a collection of
featured adult cardiac articles in press from the Journal of Thoracic and Cardiovascular
Surgery (JTCVS). To read the latest issue,
browse the feature video library and other journal
highlights please visit www.jtcvs.org.
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Impact of redo
sternotomy on proximal aortic repair: Does previous
aortic repair affect outcomes?
Harleen K. Sandhu, MD, MPH, Akiko
Tanaka, MD, PhD, Syed Taha Zaidi, BS, Alexa Perlick,
BS, Charles C. Miller III, PhD, Hazim J. Safi, MD, FACS,
Anthony L. Estrera, MD, FACS
sternotomy is associated with increased risk for short-
and long-term mortality after proximal aortic repair.
Previous repair did not add further risk above that
attributable to redo sternotomy.
Redo aortic surgery—Do not be afraid of the past
Ettorino Di Tommaso, MD, Pierpaolo
Chivasso, MD, Vito Domenico Bruno, MD, PhD
Proximal aortic re-operations are
associated with worse outcomes than those of
first-time operations, but their results are not
affected by the previous operation.
AORTIC VALVE: BASIC SCIENCE
mechanisms for osteogenic differentiation of human aortic
valve interstitial cells
Yongjun Wang, MD, Xiaoxiong Xiao,
MD, Tingwen Zhou, MD, Dong Han, MD, Nianguo Dong, MD
overexpression is linked with aortic valve
calcification. A positive feedback loop between HuR and
lncRNA MALAT1 promotes osteogenic differentiation of
Blame the sculptors for the heart of stone—Uncovering
cellular mechanisms of aortic valve calcification
Daniyil A. Svystonyuk, PhD, Paul W.M.
Fedak, MD, PhD, FRCS(C)
Uncovering cellular mechanisms of
progressive aortic valve calcification may offer
unique insights into potential therapeutic targets
and more precise risk prediction.
Why bother? The case for understanding interstitial
cells in the aortic valve
William E. Stansfield, MD
differentiation in aortic valve interstitial cells
may enable preventive treatments that delay or slow
AORTIC VALVE: EXPERT OPINION
mother nature: The Valsalva graft
Ruggero De Paulis, MD, Raffaele
Scaffa, MD, Luca Weltert, MD, Andrea Salica, MD
A few key
steps are necessary for a correct aortic valve
reimplantation into a Valsalva conduit. After the
procedure the original spherical shape of the graft
changes into a trilobate morphology.
Steps toward understanding the root of the issue
Andrew Mesher, MD, Muhammad Aftab, MD,
Thomas G. Gleason, MD, T. Brett Reece, MD
The evolution in understanding of
the aortic root anatomy has spurred both
technologic and conceptual advances in the surgical
approach to the aortic root.
mitral annuloplasty ring design reduces loading in the
Beatrice E. Ncho, MS, Eric L.
Pierce, PhD, Charles H. Bloodworth IV, MS, Akito Imai,
MD, Keitaro Okamoto, MD, Yoshiaki Saito, MD, Robert C.
Gorman, MD, Joseph H. Gorman III, MD, Ajit P.
collagen and holding strength of the posterior annulus
suggest high risk of dehiscence. A materially
heterogeneous ring can decrease this risk by reducing
posterior suture forces.
Mitral valvuloplasty rings: Do they make the
Manuel J. Antunes, MD, PhD, DSc
Mitral valvuloplasty is widely
performed. Rings of different types, shapes, and
sizes are used in most cases, but there is little
scientific evidence of superiority of 1 over the
Another step in the journey toward the “perfect” mitral
Vito Domenico Bruno, MD, PhD
How far can the knowledge of mitral
valve repair go? Can we achieve a “perfect” repair?
MITRAL VALVE FEATURED VIDEO
Optimized annuloplasty ring
EDUCATION: INVITED EXPERT OPINION
Invited Expert Opinion from John
S. Ikonomidis, MD, PhD
figure from Jennifer S. Lawton, MD Commentary
solutions for revitalization and repopulation of the
surgeon-scientist pool are discussed, starting at the
trainee level and progressing through mid- and late-
Opposing forces will lead to surgeon scientist
S. Lawton, MD
Our patients depend on us to
challenge the status quo; however, cardiothoracic
surgeon scientists face significant barriers and
extinction if aggressive measures are not taken.
Nobody roots for Goliath
H. Harken, MD
I have not encountered successful
academic surgical programs in the absence of
charismatic surgical leaders (like Dr Ikonomidis or
Gene Moore in Denver). And Goliath should not
anticipate much help.