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| DYRK2, a Dual-specificity Tyrosine-(Y)- Phosphorylation-regulated Kinase Gene, Expression can be a Predictive Marker for Chemotherapy in Non-small Cell Lung Cancer | |
Shin-ichi Yamashita, Katsunobu Kawahara; Surgery II, Oita University Faculty of Medicine, Yufu, Japan
Methods: DYRK2 expression in 157 patients with NSCLC were evaluated by immunohistochemistry(IHC) and quantitative RT-PCR. The correlation between the expression levels of this gene and clinicopathological factors were investigated. In the other series, forty patients with recurrent disease after surgery received several combinations of platinum-based chemotherapy. Chemotherapy effectiveness was evaluated according to RECIST criterion and the relationship between clinical effectiveness and the expression levels of this gene by IHC were evaluated. Results: We could not find any correlation between age, sex, pathological stage, tumor size, histological type and DYRK2 expression. However, this gene expression was significantly related to nodal metastases (P<0.05). Overall response rate is 22.2% (4 out of 18) in DYRK2 positive group compared with 4.5% (1 out of 22) in negative group. On the other hand, 17 PD (progressive disease) is consisted of 3 DYRK2 positive patients and 14 DYRK2 negative patients.(p=0.0086) The median time to the progression of disease was 120 days in the DYRK2 negative group, as compared with 310 days in the DYRK2 positive group(HR=1.984, 95% CI=[1.039-3.788], p=0.034). Conclusion: Our study showed that DYRK2 has the critical role of nodal metastases in NSCLC. Furher, patients with recurrent NSCLC and DYRK2-positive tumors derived a substantial benefit from chemotherapy, as compared with patients with DYRK2-negative tumors. 
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