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Effect of Partial Thrombosis on Distal Aorta after Repair of Acute DeBakey Type I Aortic Dissection
Suk-Won Song1, Byung-Chul Chang2, Bum-Koo Cho2, Kyung-Jong Yoo2; 1Yondong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, South; 2Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, South

Objective: Patency or thrombosis of the residual aorta after repair of acute DeBakey type I aortic dissection has been found to predict long-term outcome. However, prognostic implications of partial thrombosis of the residual aorta have not yet been elucidated. We sought to analyze the impact of partial thrombosis on segmental growth rates, distal reprocedures, and long-term survival.
Methods: One hundred eighteen consecutive patients (55% male; mean age, 60 years) with acute DeBakey type I aortic dissection underwent aggressive resection of the intimal tear and open distal anastomosis (1997-2007). Hospital mortality was 17.8%. Survivors had serial computed tomographic scans: digitization yielded distal segmental dimensions.
Segment-specific average rates of enlargement and factors influencing faster growth were analyzed. Distal reprocedures and patient survival were examined.
Results: Sixty-six (61%) patients had imaging data sufficient for growth rate calculations. The median diameters after repair were as follows: aortic arch, 3.5 cm; descending aorta, 3.6 cm; and abdominal aorta, 2.4 cm. Subsequent growth rates were 0.34, 0.51, and 0.35 mm/y, respectively. Partial thrombosis of the residual aorta predicted greater growth in the distal aorta (p = 0.005). There were 13 distal aortic reprocedures (8 stent graft insertions, 5 reoperations) for 10 years, and reprocedures-free survival was 66%. Partial thrombosis (p = 0.002), or complete patency (p = 0.008) predicted greater risk of aorta-related reprocedures. Cox proportional hazard analysis revealed eGFR lesser than 60ml/min/1.73m2 (p = 0.030), reintubation (p = 0.002), and partial thrombosis (p = 0.023) were independent predictors for poor long-term outcome.
Conclusion: Partial thrombosis of the false lumen after repair of acute DeBakey type I aortic dissection, as compared with complete patent or thrombosis, is a significant independent predictor of aortic enlargement, aorta-related reprocedures, and poor long-term outcome. Survivors who had partial thrombosis after repair of aortic dissection require meticulous and frequent follow-up due to a high risk of deterioration after discharge.


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