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| Long-term Survival and Recurrence in Patients with Resected Subcentimeter Non-Small Cell Lung Cancer |
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Back to 86th Annual Meeting Back to Program Outline Objective: With the widespread use of computed tomography and emergence of screening programs, non-small cell lung cancer (NSCLC) is increasingly detected at the subcentimeter level. Very few studies have reported the long-term survival and recurrence patterns after resection of subcentimeter NSCLC. Methods: We conducted a retrospective review of a prospectively acquired data-base over a 14-year period to identify patients with surgically resected NSCLC 1 cm or less. Medical records were reviewed, and survival data was analyzed using the Kaplan-Meier method. Results: There were 83 patients (27 men, 56 women) with mean age of 66 years (range 42 - 85). Mean tumor size was 0.86 cm (range 0.20 - 1.00). Lobectomy was performed in 69 patients, bi-lobectomy in 1, pneumonectomy in 1, segmentectomy in 5 and wedge resection in 7. Postsurgical stage was IA in 70 patients, IB in 4, IIA in 2, IIB in 1, IIIA in 1, IIIB in 4, and IV in 1. Mean follow-up was 41 months. There was one hospital death (1.2%). Six recurrences (7.2%) occurred following resection. Five of the thirteen non-IA patients (38.5%) developed recurrent cancer. Five and ten year overall survival was 86% and 71%, respectively, while the disease-free survival was 89% at both timepoints. Of the 70 stage IA patients, there was 1 recurrence (1.4%). Five and ten year overall survival was 94% and 76%, respectively, while the disease-free survival was 97% at both timepoints. Conclusions: Eighty-four percent of patients with subcentimeter NSCLC have stage IA disease. Following surgical resection of subcentimeter IA disease, recurrence is rare and long-term survival is excellent. 
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